Naslov
Adamantyl phencyclidine - a potential effective radioprotector

Autori
Ferle-Vidović, Ana ; Petrović, Danilo ; Šuman, Lidija ; Škare, Danko ; Mlinarić-Majerski, Kata ; Kaselj, Mira ; Lasić, Mila

Izvornik
Periodicum biologorum (0031-5362) 97 (1995), 1; 41-44

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Phencyclidine ; Adamantyl derivate ; radioprotection mice ; cultured cells

Sažetak
Adamantyl phenicyclidine - a potential efective radioprotector Background and purpose: The compound phencyclidine (PCP) has been used in veterinary medeicine because of its anesthetic and analgetic properties for a rather long time, but its toxicity always was a limiting factor, and that was the reason that it was never accepted in human medicine.We have tested radioprotective effects of PCP and Ad-PCP in gama-irradiated cultured cells and in mice. From our results it can be concluded that this adamantyl analog of phencyclidine has reduced toxicity and increased radioprotection in cells and mice and therefore deserves attention and might be interesting for further investigation.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA