Naslov
Tissue distribution of lipid peroxidation product acrolein in human colon carcinogenesis

Autori
Žarković, Kamelija ; Uchida, Koji ; Kolenc, Danijela ; Hlupić, Ljiljana ; Žarković, Neven

Izvornik
Free Radical Research (1071-5762) 40 (2006), 6; 543-552

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
4-hydroxynonenal; acrolein; colon carcinogenesis; lipid peroxidation; oxidative stress; p53

Sažetak
Lipid peroxidation product acrolein, well-known pollutant in tobacco and automotive smoke, accumulates in vivo bound to proteins. It suppresses p53 synthesis acting as potent carcinogenic factor for oral, respiratory and bladder carcinomas, while its possible association with colon carcinogenesis was not studied so far. We used genuine monoclonal antibody to evaluate immunohistochemical distribution of acrolein - protein adducts in 113 human colon tumours. The presence of acrolein - protein adducts was increasing with respect to colon carcinogenesis, from moderate appearance in tubular and villotubular low-grade adenomas to abundant and diffuse distribution in high-grade villotubular adenomas and Dukes A carcinomas. However, in advanced Dukes B and C carcinomas acrolein was hardly noticed, although, its protein adducts were found abundant in non-malignant colon epithelium of these patients. There was no relationship between p53 and acrolein distribution. According to these findings, acrolein seems to be lipid peroxidation product associated with transition from benign into malignant colon tumours.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

Napomena
DOI: 10.1080/10715760500370048

POVEZANOST RADA