Naslov
Ligacija CD3 molekule niske gustoće na R1.1 stanicama dovodi do modulacije Fas-receptora (CD95)
(Ligation of low-density CD3 molecules on R1.1 cell line leads to modulation of Fas-receptor (CD95))

Autori
Gabrilovac, Jelka ; Antica, Mariastefania

Izvornik
40 godina molekularne biologije u Hrvatskoj, Zagreb, 25. 11.1998., poster.

Vrsta, podvrsta
Ostale vrste radova, ostalo

Godina
1998

Ključne riječi
T limfocit; CD3; aktivacija; Fas-receptor kapa opioidni receptor
(T lymphocytes; CD3; activation; Fas-receptor; kappa opioid receptor)

Sažetak
R1.1 cell-line, originating from mouse thymoma, due to its constitutive expression of kappa opioid receptors (KOR), could be a model for studying the role of kappa opioids in differentiation, maturation, and activation of T lymphocytes in the thymus. In order to use the R1.1 as a model for differentiation studies, the stage of its maturity was characterised by using specific monoclonal antibodies against differentiation antigens of thymus cells. The data obtained have shown that R1.1 cells represent a very immature stage of T-cell differentiation, expressing low density CD3 and CD4, and no CD8. Due to CD3, R1.1 cells are able to respond to activation by anti-CD3 antibody, in spite of their immature phenotype.

Izvorni jezik
Engleski

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