Pregled bibliografske jedinice broj: 257998
Ionization, lipophilicity and solubility properties of repaglinide
Ionization, lipophilicity and solubility properties of repaglinide // Journal of pharmaceutical and biomedical analysis, 41 (2006), 3; 866-871 doi:10.1016/j.jpba.2006.01.056 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 257998 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Ionization, lipophilicity and solubility
properties of repaglinide
Autori
Mandić, Zoran ; Gabelica, Vesna
Izvornik
Journal of pharmaceutical and biomedical analysis (0731-7085) 41
(2006), 3;
866-871
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
repaglinide ; acid-base properties ; ionization macro- and microconstants ; lipophilicity ; solubility
Sažetak
Potentiometric and spectrophotometric titrations were used for the determination of ionization behviour, lipophilicity and solubility profile of repaglinide. Acid-base equilibria were characterized by means of protonation macro- and microconstants using Target Factor Analysis of spectrophotometric data. Lipophilicity profiles were evaluated by determination of partition coefficients of neutral and ionized forms of repaglinide in biphasic octanol/water system. The intrinsic solubility of repaglinide were determined from the solubility data and temperature dependence of intrinsic solubilities were evaluated using van't Hoff equation.
Izvorni jezik
Engleski
Znanstvena područja
Kemija, Kemijsko inženjerstvo
POVEZANOST RADA
Projekti:
0125010
Ustanove:
Pliva-Istraživački institut,
Fakultet kemijskog inženjerstva i tehnologije, Zagreb
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
