Naslov
Immunopathogenesis of hemorrhagic fever with renal syndrome in humans

Autori
Markotić, Alemka ; Rabatić, Sabina ; Gagro, Alemka ; Sabioncello, Ante ; Kuzman, Ilija ; Dekaris, Dragan

Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), znanstveni

Izvornik
Emergence and control of rodent-borne viral diseases. Emerging diseases. Proceedings / Saluzzo, J F ; Dodet, B - Amsterdam : Lausanne : New York (NY) : Oxford : Paris : Shannon : Tokyo : Elsevier, 1999, 125-131

Skup
Emergence and Control of Rodent-borne Viral Diseases (Hantaviral and Arenal Deiseases)

Mjesto i datum
Annecy, Francuska, 28.10.1998. - 31.10.1998

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
hemmorrhagic fever with renal syndrome (HFRS); hantaviruses; immunopathogenesis; Puumala virus; Dobrava virus

Sažetak
Hantaviruses (HV) cause an important human illness, hemorrhagic fever with renal syndrome (HFRS). Clinically, HFRS is manifested mainly by fever, variable degrees of circulatory failure, hemorrhate and renal failure, with additional symptoms from other organs and systems. Several studies support the view that HFRS is an immune disease with thrombocytopenia and vascular dysfunction as the central physiological alterations. Still, little is known about the immunopathogenesis of HFRS. This report is an attempt to indicate the possible immune mechanisms and analyze the elements (e.g. endothelial cells, monocytes/macrophages, platelets, possible professional antigen-presenting cells, T cells, B cells, antibodies, immune complexes, cytokines, chemokines and other mediators of inflammation) which could play a role in HFRS immunopathogenesis. Still, many gaps remain in our understanding of the network of immunological and pathological changes that occur. Further studies on the immunopathogenicity of HFRS should be undertaken, as such knowledge would be useful for the production of effective vaccines and antiviral agents against HTV.

Izvorni jezik
Engleski

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