Naslov
Influence of Mobile Phase and Temperature on Separation of 1, 1’ -Binaphthyl-2, 2’ -Diol Enantiomers with Brush Type Chiral Stationary Phases Derived from L-Leucine

Autori
Landek, Goran ; Vinković, Marijana ; Kontrec, Darko ; Vinković, Vladimir

Izvornik
Chromatographia (0009-5893) 64 (2006), 7/8; 469-473

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Column liquid chromatography; NMR spectroscopy; Enantiomer separation; 1; 1'-Binaphthyl-2; 2'-diol; 3; 5-dinitrobenzoyl-L-leucine; Chiral recognition mechanism

Sažetak
1, 1'-Binaphthyl-2, 2'-diol (BINOL) was analysed on three different chiral stationary phases comprising 3, 5-dinitrobenzoyl-L-leucine as chiral selector. Chromatographic data were related to NMR measurements performed for the mixture of the soluble chiral selector and individual enantiomers of BINOL. The results indicate that the most important interactions for complexation are H-bondings accomplished through the hydroxyl protons of BINOL with carbonyl groups of 3, 5-dinitrobenzoyl-L-leucine. Interactions between 3, 5-dinitrobenzoyl and naphthyl aromatic units are not observed and that could explain the large variations of NMR spectra and HPLC chromatograms recorded at different temperatures.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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