Naslov
Function of granulocytes in B-chronic lymphatic leukaemia

Autori
Dekaris, Dragan ; Handl, Sonja ; Sabioncello, Ante ; Rabatić, Sabina

Izvornik
Blut (0006-5242) 61 (1990); 354-357

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
leukaemia; B-cell; chronic; B-CLL; granulocytes; phagocytosis; spontaneous mobility; humans

Sažetak
To study the function of granulocytes in patients with B-cell chronic lymphatic leukaemia (B-CLL), granulocytes were separated from peripheral blood of 48 patients (mean age: 69 years) and 35 apparently healthy age-matched volunteers. Spontaneous mobility, ingestion, digestion and antibody dependent cellular cytotoxicity (ADCC) of granulocytes were assessed. Decreased spontaneous mobility was found in granulocytes from patients with B-CLL but between the two groups no detectable differences were encountered in the other parameters tested. No alterations of granulocytes functions were found to be correlated with clinical stages of B-CLL. If granulocytes functions were compared in treated (chlorambucil, steroids) and untreated patients, a significant decrease in digestion was found in treated patients.

Izvorni jezik
Engleski

POVEZANOST RADA