Naslov
Utjecaj morfološkog tipa stanica na ekspresiju bcl-2, ki-67 i p-53 u uvejalnim melanomima.
(Effect of morphologic cell types on the expression of bcl-2, ki-67 and p-53 in uveal melanomas.)

Autori
Krvavica, Ana ; Talan-Hranilović, Jasna ; Belicza, Mladen

Izvornik
Acta clinica Croatica (0353-9466) 41 (2002), 2; 179-180

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, kratko priopcenje, stručni

Ključne riječi
bcl-2onkoprotein; ki-67 onkogen; p-53 supresorski gen; uvejalni melanom
(bcl-2oncoprotein; Ki-67 oncogene; p-53supressor gene; uveal melanoma)

Sažetak
Uveal melanomas are known to be less aggressive malignant tumors compared with melanoma of other localisations but the same morphologic characteristics.We hypothezised that immunohistochemical determination of expression of the known proliferation markers bcl-2, ki-67and p-53 as a supressor gene marker, could better explain the biological behavior of uveal melanoma vs. melanoma of other localisations.Thirty cases of primary uveal melanoma of two levels of invasion were tested retrospectively for the presence of bcl-2, Ki-67 andp-53 proteins with with the indirect peroxidase-antiperoxidase immunoenzyme method and three step ABC/AP method.The intensity of reaction was assessed by semiquantitative method.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

Napomena
Rad je prezentiran na skupu 13th Ljudevit Jurak International Symposium of Comporative Pathology, održanom od 07.-98.07.2002., Zagreb, Hrvatska.

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