Naslov
Apolipoprotein E Genotypes and Metabolic Risk Factors for Coronary Heart Disease in Middle-aged Women

Autori
Čubrilo-Turek, Mirjana ; Stavljenić-Rukavina, Ana ; Sertić, Jadranka ; Zrinski-Topić, Renata ; Turek, Stjepan ; Grgac, Goran ; Ljubojević, Nikola

Izvornik
Collegium Antropologicum (0350-6134) 22 (1998), 1; 149-155

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
apolipoprotein E; coronary heart disease; population genetics; anthropology

Sažetak
Apo E genotypes and plasma metabolic risk factors (total cholesterol, triglycerides, HDL and: LDL cholesterol, total/HDL cholesterol ratio, lipoprotein. Lp (a), apolipoprotein A-I, A-II, apo B, and apo E) were determined in 134 healthy middle-aged (X +/- SD 49.62 +/- 4.83) women. The aim of this study was to investigate metabolic risk markers according to various apo E genotypes, and to evaluate a possible risk for coronary heart disease. The results revealed that the frequencies of apo E3/3 are the most frequent (46%), followed by E4/4 (2%), E3/4 (14%), E2/3 (14%), and E2/4 (2%) in the middle-aged women. Higher mean triglycerides, LDL-C and apo B levels were found with apo E3/4, and lower mean levels of HDL-C i.e. apo A-I than in, other analyzed genotypes. Greater mean of total/HDL ratio and lower levels of apo A-II were seen with E2/4. Serum lipoprotein Lp (a) concentration was higher in. women with genotypes E3/3. Apo E concentration was the lowest with genotypes E4/4, i.e. the highest with E2/3. Serum total cholesterol fended to be higher in women with genotypes E4/4. Genotype E3/4 is connected with the highest concentrations of(Xi SD) triglycerides (1.74 +/- 078), LDL (4.28 +/- 1.88), apo B (1.03 +/- 0.32) and with the lowest concentrations of HDL cholesterol (1.11 +/- 0.21) in. the relation to the other analyzed genotypes. This group of women could possibly represent high risk women for CHD. Genotype E3/3 is associated with the highest concentration of independent genetic risk marker for CHD, lipoprotein Lp (a) (0.19 +/- 0.27). The genotype E4/4 has the highest concentration of total cholesterol (5.93 +/- 1.01), and has to be taken in account for risk evaluation in women. High level of apo E (0.11 +/- 0.05) and low level of apo A-I (1.80 +/- 0.44) were associated with E2/3 genotypes. The significance of E3/4 with the high total/HDL ratio (5.52 +/- 2.21) and low apo A-II (0.53 +/- 0.09) is important indicator, because total/HDL cholesterol ratio represents independent Established Risk Factor (ERF) for CHD. Apolipoprotein E genotypes as genetic markers and investigation of serum metabolic risk markers appear to be important in view for further evaluation. of high risk women for CHD in our population.

Izvorni jezik
Engleski

Znanstvena područja
Etnologija i antropologija

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