Naslov
Synthesis, spectroscopy and biological activity of palladium(II) acetate complexes with quinolylmethylphosphonates

Autori
Tušek-Božić, Ljerka ; Balzarini, Jan ; De Clercq, Erik

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
1st European Chemistry Congress, Abstract Book / Naray-Szabo, Gabor - Budimpešta : European Association for Chemical and Molecular Sciences, 2006, 373-373

Skup
1st European Chemistry Congress

Mjesto i datum
Budimpešta, Mađarska, 27.08.2006. - 31.08.2006

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
palladium(II) acetate complexes; quinolylmethylphosphonate complexes; antitumor and antiviral activity

Sažetak
There is a current interest in platinum(II) and palladium(II) complexes with nitrogen donor ligands not only because of their wide-range application in organic synthesis and catalysis, but also owing to their biological and pharmacological importance. A number of these compounds have shown good cell growth inhibitory effects. In this field our study is directed to complexes of quinoline and aniline-based alkyl phosphonates. We report here the synthesis, some spectroscopic properties and biological evaluation of new palladium(II) acetate complexes of diethyl 8-quinolylmethylphosphonate and monoethyl 2-quinolylmethylphosphonate (2-Hmqmp). These organophosphorus ligands form different type of binuclear acetate-bridged complex, that with [C, N] and [N, O] cyclopalladation, respectively. Comparative studies were performed with results obtained for the selected palladium(II) chloride complexes of the same phosphonate ligands and a structure-activity relationship was discussed. It was found that most of complexes demonstrated distinct in vitro cytostatic activity, but showed no or only marginal antiviral activity in different assay systems.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA