Pregled bibliografske jedinice broj: 256247
Lack of Proper Follicular Dendritic Cells Networks May Prevent Germinal Center Formation in Both Bcl-3 and p52 KO Mice formation in both Bcl-3 and p52 KO Mice.
Lack of Proper Follicular Dendritic Cells Networks May Prevent Germinal Center Formation in Both Bcl-3 and p52 KO Mice formation in both Bcl-3 and p52 KO Mice. // Abstract Book of the Keystone Symposia Conference on Cellular and Molecular Biology of Dendritic cells, Sanata Fe, New Mexico, USA / Steinman, Ralph ; Banchereau, Jacques (ur.).
Santa Fe (NM), 1997. (pozvano predavanje, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 256247 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Lack of Proper Follicular Dendritic Cells Networks May Prevent Germinal Center Formation in Both Bcl-3 and p52 KO Mice formation in both Bcl-3 and p52 KO Mice.
(Lack of Proper Follicular Dendritic Cells Networks May Prevent Germinal Center Formation in both Bcl-3 and p52 KO Mice)
Autori
Poljak, Ljiljana ; Carlson, Louise ; Cunningham Kirk ; Kosco-Vilbois Marie ; Siebenlist Ulrich
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
Abstract Book of the Keystone Symposia Conference on Cellular and Molecular Biology of Dendritic cells, Sanata Fe, New Mexico, USA
/ Steinman, Ralph ; Banchereau, Jacques - Santa Fe (NM), 1997
Skup
Keystone Symposia on Cellular and Molecular Biology of Dendritic Cells
Mjesto i datum
Santa Fe (NM), Sjedinjene Američke Države, 07.02.1997. - 13.02.1997
Vrsta sudjelovanja
Pozvano predavanje
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
Germinal center; follicular dendritic cells; NF-kB activation
(Germinal center; follicular dendritic cells; NF-Kb activation)
Sažetak
Maturation of FDC is impaired in mice deficient in p52, a subunit of NF-kB transcription factors, as well as in mice deficient in Bcl-3, a regulator of NF-kB activity. However, while the formation of FDC networks is only partially affected in Bcl-3 KO mice, this network is completely missing in p52 Kos. Consistent with loss of FDC networks, memory response appear to be defective in both mice. Adoptive transfer of wild type bone marrow cells into p52 recipients failed to restore the ability to form FDC networks, suggesting a critical defect in nonhematopoietic/stromal cell compartment in both knockout mice. Potentially related to this defect in stromal cells, we observed impaired extracellular matrix formation in the marginal zone of p52 KO spleens.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
