Pregled bibliografske jedinice broj: 256217
Critical role for p52 containing NF-kB complexes in formation of follicular dendritic cell networks
Critical role for p52 containing NF-kB complexes in formation of follicular dendritic cell networks // Abstracts of papers presented at the LXIV Cold Spring HArbour Symposium on Signaling&Gene Expression in the Immune System / Bruce Stillman (ur.).
Lahti: Cold Spring Harbor Laboratory (CSHL), 1999. (poster, međunarodna recenzija, sažetak, znanstveni)
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Naslov
Critical role for p52 containing NF-kB complexes in formation of follicular dendritic cell networks
(Critical role for p52 containing NF-kB complexes in fomration of follicular dendritic cell networks)
Autori
Poljak, Ljiljana ; Carlson, Louise ; Cunningham, Kirk ; Kosco-Vilbois, Marie, Siebenlist Ulrich
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
Abstracts of papers presented at the LXIV Cold Spring HArbour Symposium on Signaling&Gene Expression in the Immune System
/ Bruce Stillman - Lahti : Cold Spring Harbor Laboratory (CSHL), 1999
Skup
Signaling&Gene Expression in hte Immune System
Mjesto i datum
Cold Spring Harbor (NY), Sjedinjene Američke Države, 02.06.1999. - 07.06.1999
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
follicular dendritic cells; NF-kB complexes; genes activation
Sažetak
Follicular dendritic cells(FDCs)are antigen repesenting cells located in B cell zones of secondary lymphoid organs.They do not process antigen, instead can capture antigen in its native form and present it for prolonged periods, a function thought to be important for generation of memory response. The cellular origin of FDC and their maturation to cells forming networks in response to antigen remains to be defined. Maturation of FDCs is impaired in mice deficient in p52, a subunit of NF-kB transcription factors, as well as in mice deficient in Bcl-3, a regulator of NF-kB activity. However, while the formation of FDC networks is only partially affected in Bcl-3 KO mice, this network is completely missing in p52 KOs. Consistent with loss of FDC networks, memory response appear to be defective in both mice. Adoptive transfer of wild-type bone marrow cells into p52 recipients failed to restore the ability to form FDC networks, suggesting a critical defect in a non-hematopoietic/stromal cell compartment in both knock-out mice. Potentially related to this defect in stromal cells, we observed impaired extracellular matrix formation in the marginal zone of p52 KO spleens.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
