Pregled bibliografske jedinice broj: 255078
Sequential Kinetic Resolution Catalysed by Halohydrin Dehalogenase
Sequential Kinetic Resolution Catalysed by Halohydrin Dehalogenase // Organic Letters, 8 (2006), 19; 4227-4229 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 255078 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Sequential Kinetic Resolution Catalysed by Halohydrin Dehalogenase
Autori
Majerić Elenkov, Maja ; Tang, Lixia ; Hauer, Bernhard ; Janssen, Dick B.
Izvornik
Organic Letters (1523-7060) 8
(2006), 19;
4227-4229
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
sequential kinetic resolution; halohydrin dehalogenase; cyanide
Sažetak
A sequential kinetic resolution catalyzed by halohydrin dehalogenase was employed for the synthesis of two valuable enantiopure building blocks. Resolution of methyl 4-chloro-3-hydroxybutanoate methylester using a Trp249Phe mutant of halohydrin dehalogenase yielded methyl 4-cyano-3-hydroxybutanoate methylester with 96.8% ee (40% yield) and methyl 4-chloro-3-hydroxybutanoate methylester with 95.2% ee (41% yield). This reaction is carried out in aqueous solution under mild conditions and provides access to a useful statin side-chain building block
Izvorni jezik
Engleski
Znanstvena područja
Kemija
POVEZANOST RADA
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
Uključenost u ostale bibliografske baze podataka::
- Chemical Abstracts
