Naslov
New peptidoglycans and adamantyltripeptides - immunomodulating properties and structure-activity relationship

Autori
Tomašić, Jelka ; Ljevaković, Đurđica ; Vranešić, Branka ; Hršak, Ivo

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts, Godišnji sastanak hrvatskih biokemičara, Zagreb, 17.06.- 18.06. 1993. / - , 1993, 59-59

Skup
Godišnji sastanak hrvatskih biokemičara, 1993.

Mjesto i datum
Zagreb, Hrvatska, 17.06.1993. - 18.06.1993

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Domaća recenzija

Ključne riječi
peptidoglycan monomer; adamantyltripeptides; N-acetylmuramyl-L-alanyl amidase

Sažetak
Structure-activity relationship of several biologically active compounds comprising peptidoglycan structure was studied. Peptidoglycan monomer (PGM) and the derivative, Boc-Tyr-PGM were hydrolyzed by N-acetylmuramyl-L-alanyl amidase yielding the disaccharide GLcNAc-MurNAc and corresponding peptide portions of the respective molecules. In several experimental models, the peptides obtained by enzymic hydrolysis exhibited immunomodulating and antitumor properties wich could be compared to the activity of the integral parent molecules. Investigated adamantyltripeptides were diastereoisomers and were tested separately. Both compounds showed antimetastatic and immunomodulating activity, although in some models the activity of diastereoisomers was expressed to a different extent.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Temeljne medicinske znanosti

POVEZANOST RADA