Naslov
Effetti di BRMs sulle proprieta antitumorali di ciclofosfamide, cisplatino, 5-FU e dacarbazina in tumori solidi avanzati
(The effects of BRMs on the antitumor activity of ciclofosfamide, cisplatine, 5-FU and dacarbazine in advanced solid tumors)

Autori
Dašić, Gorana ; Pacor, S. ; Bergamo, A. ; Salerno, G. ; Tomašić, Jelka ; Vranešić, Branka ; Sava, Gianni

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Libro degli Absracts, X Congresso nazionale della associazione italiana di munofarmacologia, Perugia. 10.07.-11.07. 1994. / - , 1994, 69-69

Skup
X Congresso nazionale della associazione italiana di munofarmacologia

Mjesto i datum
Perugia, Italija, 10.07.1994. - 11.07.1994

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Adamantil-derivato; peptidoglicano; Lewis lung carcinoma; ciclofosfamide; cisplatino; 5-FU; dacarbazina
(Adamantyl derivatives; peptidoglycan monomer; Lewis lung carcinoma; ciclofosfamide; cisplatine; 5-FU; dacarbazine)

Sažetak
A new biological response modifier, L-(adamant-2-yl)glycyl-L-alanyl-D-isoglutamine hydrochloride (AdTP, recently synthesized and characterized for antitumor, antiviral and immunomodulating properties, was studied in comparison to the peptidoglycan monomer (PGM) isolated from Brevibacterium divaricatum to test the effects of their use concomitant to that of anticancer cytotoxic drugs such as cyclophosphamide, 5-FU, cisplatin and dacarbazine. The experiments performed using Lewis lung carcinoma and MCa mammary carcinoma in CBA mice, indicated that AdTP and PGM increased some immunological parameters of lymphocytes isolated from the spleens of treated mice. AdTP increased the effect of 5-FU on lung metastases but failed to show any increase in life expectancy with the treatment performed

Izvorni jezik
Ita

Znanstvena područja
Kemija, Biologija, Temeljne medicinske znanosti

POVEZANOST RADA