Naslov
The Role of Immune Privilege in Corneal Allograft Survival

Autori
Dekaris, Iva ; Gabrić, Nikica ; Raštegorac, Petar

Izvornik
Klinička medicina (1330-058X) 5 (1998), 1; 18-24

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, stručni

Ključne riječi
Corneal transplantation; Imunological privilege; ACAID

Sažetak
Corneal transplantation has been performed on animal subjects for over 150 years and on human patients for over 80 years. In the United States alone, 45, 000 corneal transplants are performed each year, with a success rate in uncomplicated cases of over 90%. The extraordinary success of corneal transplantation is attributed to the "immunological privilege" of the cornea and the eye. Immune privilege is a dynamic, physiological process that enables the eye (and some other special body sites) to accept foreign tissue grafts for an extended or even indefinite time as compared to tissue placement at a conventional site. Privilege in the eye results from eye-dependent modifications in the induction (afferent limb) and expression (efferent limb) of immunity to intraocular antigens. Important features for the maintenance of the immune privilege include integrity of the blood-ocular barrier, the virtual absence of lymphatics, an afferent drainage pathway that is almost exclusively via the blood vasculature, and an immuno-suppressive intraocular microenvironment. This microenvironment is comprised of variety of cytokines and neuropeptides that (1) impair antigen-driven activation of primed and alloreactive T cells, (2) suppress effector functions of activated macrophages, and (3) modify the antigen processing and presenting properties of professional antigen presenting cells.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA