Naslov
Inhibition of monocyte spreading. A direct in vitro test for assessing delayed-type hypersensitivity in man

Autori
Dekaris, Dragan ; Silobrčić, Vlatko ; Mažuran, Renata ; Kadrnka-Lovrenčić, Magda

Izvornik
Clinical and experimental immunology (0009-9104) 16 (1974); 311-320

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
monocyte spreading ; delayed-type hypersensitivity ; tuberculin

Sažetak
An in vitro expression of delayed type hypersensitivity to tuberculin was tested in Mantoux positive and Mantoux negative persons. Their lymphocytes and monocytes were isolated from venous blood and incubated in vaseline chambers with or without tuberculin. In the presence of tuberculin, a substantially lower percentage of Mantoux positive persons spread, than monocytes of Mantoux negative persons. This antigen-induced inhibition of monocyte spreading seems to be a reliable measure of tuberculin hypersensitivity, since it occurs only in Mantoux positive persons and correlates well with the intensity of the tuberculin skin reaction. Reproducibility of the test and the speed with which it is performed could constitute a basis for the use of monocyte spreading inhibition in clinical studies of cell-mediated immune reactions.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

Napomena
Rad je kao pozvano predavanje prezentiran na skupu Conference on Host-environment interactions in the etiology of cancer in man : Implementation in Research, u organizaciji International Agency for Cancer Research, Lyon ; održanom u Primoštanu, Jugoslavija od 27.08-02.09 1972.g. , objavljen u Knjizi sažetaka str. 68.

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