Naslov
Changes of mouse spleen lymphocyte phenotype after single i.v. administration of adamantyltripeptides.
(Changes of mouse spleen lymphocyte phenotype after single i.v. administration of adamantyltripeptides. Joint Annual Meeting 1995, Ostereichische Gesellschaft fur Allergologie und Immunologie and Gesellschaft fur Immunologie 27.09.-30.09. 1995.)

Autori
Vranešić, Branka ; Dašić, Gorana ; Tomašić, Jelka ; Rabatić, Sabina

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts, Joint Annual Meeting 1995, Ostereichische Gesellschaft fur Allergologie und mmunologie and Gesellschaft fur Immunologie, Beč, Austrija, 27.09.-30.09. 1995 / - , 1995

Skup
Joint Annual Meeting 1995, Ostereichische Gesellschaft fur Allergologie und Immunologie and Gesellschaft fur Immunologie

Mjesto i datum
Beč, Austrija, 27.09.1995. - 30.09.1995

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
lymphocyte phenotypes; adamantyltripeptides

Sažetak
We have shown that distribution of cells among lymphocyte population in the mouse spleen has been already affected after single administration of AdTPs. Two stereoisomers of adamantyltripeptide showed a different in vivo effect on mice spleen lymphocytes. Percentage of total T-lymphocytes (CD3+) was decreased, particularly subpopulation of cytotoxic T-lymphocytes (CD8+), after i.v. administration of AdTP2, but not with AdTP1. After i.p. administration of tested compounds, AdTP1 increased percentage of T lymphocytes (CD4+ and CD8+), while AdTP2 increased percentage of total (IaK+) and activated (CD23+) B-lymphocytes. PGM showed the same effect as AdTP2 in all experiments. Different effects of two tested stereoisomers (AdTP1 and AdTP2) on mice spleen lymphocyte should be further evaluated.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Temeljne medicinske znanosti

POVEZANOST RADA