Naslov
Composite neurocognitive phenotype correlated with schizophrenia: A grade of membership model and genetic linkage findings

Autori
Hallmayer J., Jablensky A., Woodbury M., Michie P., Kent A., Wagner J., Dragović, Milan, Salmon B., Witchmann H., Rock D., Todd J., Wynne B., D'Ercole M., Howell S., Dedmann K., Box J., and Johnston J.

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Skup
Australiasian Society for Psychiatric Reserach

Mjesto i datum
Adelaide, Australija, 2000

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
schizophrenia; endopheotype; linkage analysis; grade of membership

Sažetak
We demonstrate a novel method for constructing composite quantitative phenotypes for QTL analysis in schizophrenia. In 124 patients, 202 first-degree relatives, and 71 controls, a neurocognitive battery identified deficits (2 SD below the mean of the controls) in attention, verbal fluency, IQ and speed of processing in 62% of patients, 36 % of relatives and 7% of controls (p<0.001). We applied Grade of Membership (GoM) analysis to resolve heterogeneity and integrated the outcomes of all measures used in to 5 pure types of deficit. Patterns of deficit were found to aggregate in families and correlate with personality traits as measured by Cloninger&#8217; s TCI and Raine&#8217; s SPQ. Two of the pure types had joint heritability of 0.39, p=0.003. We genotyped 72 families (311 subjects) with markers spanning a region on chromosome 6 where positive lod scores have been reported (Schwab et al 1995). Using linear combination of GoM scores, we constructed a phenotype for variance component linkage analysis (SOLAR program, Almasy and Blangero 1998). We repeated the analysis using a single test (CPT-IP) as quantitative trait. Multipoint linkage using the GoM phenotype yielded a maximum lod score of 2.24, as compared to a lod score of 0.6 when using CPT-IP.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Psihologija

POVEZANOST RADA