Naslov
Antisaccades impairment in adults with schizophrenia, their unaffected first degree biological relatives and healthy controls

Autori
Clissa, P. ; Wynne, B. ; Badcock, J. ; Dragović, Milan ; Michie, P. ; Wichman, H. ; Johnston, J. ; Innes-Brown, H. ; Kent, A. ; Todd, J. ; Frima, R. ; Dedman, K. ; Rock, D. ; Jablensky, A.

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, neobjavljeni rad, znanstveni

Skup
Australasian Society for Psychiatrc Research

Mjesto i datum
Adelaide, Australija, 2000

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
schizophrenia; antisaccades; smooth pursuit eye tracking; endophenotype

Sažetak
Several ocular motor abnormalities have been observed in schizophrenia. Amongst these is impaired performance on the antisaccade condition of step saccade tasks. In the antisaccade condition participants are required to inhibit a reflexive saccade to a target in the periphery of one visual field, and generate a voluntary saccade to a mirror image position in the opposite visual field. This task condition is thought to primarily tap inhibitory, and to a lesser degree working memory, capacities located in the prefrontal cortex. Existing evidence shows that schizophrenics and their unaffected first-degree biological relatives have unimpaired prosaccade performance, but significantly impaired ability to inhibit reflexive saccades in the antisaccade condition. The present study examined the prosaccade and antisaccade performance of 40 clinically diagnosed schizophrenic patients, 50 unaffected first-degree biological relatives, and 30 controls free of psychiatric diagnosis. Initial analysis is consistent with existing evidence that individuals with schizophrenia show significantly poorer antisaccade performance than controls, and the antisaccade performance of first-degree biological relatives’ falls between these two groups. There was no significant difference between the groups in prosaccade performance or rates of self-correction of incorrect saccades. The presentation will report on these data and their relationship to other neurocognitive measures, in particular, sustained attention and speed of processing.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Psihologija

POVEZANOST RADA