Naslov
Clinical and morphological features of undifferentiated monomorphous GH/TSH-secreting pituitary adenoma

Autori
Škorić, Tanja ; Koršić, Mirko ; Žarković, Kamelija ; Breskovac, Ljiljana ; Bešenski, Nada ; Giljević, Zlatko ; Plavšić, Vesna

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Zbornik, 1.Slovenski endokrinološki kongres z mednarodno udeležbo / Mrevlje, F. - Ljubljana : Združenje endokrinologov Slovenije, 1998

Skup
1.Slovenski endokrinološki kongres z mednarodno udeležbo

Mjesto i datum
Radenci, Slovenija, 01.10.1998. - 03.10.1998

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
growth hormone; thyrotrophin; pituitary adenoma; somatostatin therapy; morphology

Sažetak
A 41-year-old male presented with progressive visual defects, acromegaly and hyperthyroidism. Clinically, a giant GH/TSH secreting pituitary adenoma was diagnosed. Administration of somatostatin analogue octreotide at doses of 150 ug s.c. per day inhibited the secretion of both GH and TSH. A three-week treatment with octreotide prior to surgery led to the slight visual improvement and CT scan showed some new necrotic areas within the tumor mass. Transcranial surgery was performed. By immunohistochemistry, GH, PRL and beta-hCG were detected ; TSH was negative. Electron microscopy revealed undifferentiated, monomorphous adenoma with morphological features of acidophil stem cell adenoma such as the presence of misplaced exocytoses, fibrous bodies and the frequently occuring mitochondrial gigantism. However, the tumor cells contained small secretory granules (up to 250 nm) characteristic of thyrotroph cells. Two months after the operation CT scan revealed large residual tumor. Serum GH and TSH levels were increased, TSH level was higher than before the treatment. The patient suddenly died, most probably of lethal arrhythmia. Specimens from the autopsy confirmed the previous findings concerning negative immunostaining for TSH. This undifferentiated, monomorphous GH/TSH secreting pituitary adenoma represents an entity that is unusual both in its ultrastructural features and clinical manifestations suggesting a cytogenesis from an early, undifferentiated stem cell.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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