Naslov
Laterality phenotypes in schizophrenia patients, their unaffected siblings and controls

Autori
Dragović, Milan ; Jablensky, Assen

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
The Australasian Society for Psychiatric Research

Mjesto i datum
Christchurch, Novi Zeland, 04.12.2003. - 05.12.2003

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
phenotypes; laterality; schizophrenia

Sažetak
Although behavioural indices of brain lateralisation are intercorrelated, current research in this area still focuses on isolated behavioural asymmetries, such as shift in handedness. Simultaneous integration of various laterality indices to delineate complex phenotypes might be a more productive research approach. In this study we used a version of latent class analysis - the Grade of Membership model - to describe complex lateralisation phenotypes in schizophrenic patients, their unaffected siblings and controls. The selected indices were: eye, foot and hand asymmetries ; motor proficiency ; and putative genetic indicants (parent’ s handedness, sibling’ s handedness, and familial sinistrality). Three “ pure type” lateralisation patterns were derived from schizophrenia patients and their unaffected siblings, as compared to healthy controls, where only two patterns were found. In the group of schizophrenia patients, lateralisation phenotypes (two leftward and one rightward) showed distinct clinical and behavioural profiles. One of the leftward phenotypes in schizophrenia patients displayed greater clinical severity (lower age at onset, frequent hospital admissions, and more antipsychotic medication) and poorer neurocognitive performance (lower current IQ, poorer sustained attention, and slower speed of information processing). The characterisation of pure lateralisation types in unaffected siblings revealed closer phenotypic similarity to schizophrenia patients, than to controls, thus suggesting a possible genetic effect.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Psihologija

POVEZANOST RADA