Naslov
Quantitative analysis of constitutive heterochromatin in children with acute lymphoblastic leukaemia

Autori
Roganović, Jelena ; Buretić-Tomljanović, Alena ; Radojčić Badovinac, Anđelka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
30th Meeting of the International Society of Pediatric Oncology : SIOP Meeting : Abstracts ; u: Medical and Pediatric Oncology 31 (1998) (4) 189-390 / - London : Delhi : Wiley-Liss, 1998, 334-334

Skup
Meeting of the International Society of Pediatric Oncology (30 ; 1998)

Mjesto i datum
Yokohama, Japan, 04.10.1998. - 08.10.1998

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
leukaemia; heterochromatin

Sažetak
The biological role of the constitutive heterochromatin in the human genome is a subject of numerous speculations. Of the particular interest are the investigations in the group of the patients with malignant diseases, and the suggestion that heterochromatic variants increase the risk of malignant transformation. The aim of our study was to determine the correlation of quantitative changes of the constitutive heterochromatinand malignant transformation in children in acute lymphoblastic leukaemia. The length variability of the constitutive heterochromatine of chromosomes 1, 9 and 16 was analysed in 39 children with acute lymphoblastic leukaemia and in 21 healthy controls. The analysis was carried outon slides obtained by routine method of peripheral blood culture and stained for G-banding. The objective method of linear measuring was used. A statisticaly significant shorter lengthof the heterochromatic regions of chromosome 1 was found in the children with acute lymphoblastic leukaemia compaired with control group (p<0.001), while there was no differencein the heterochromatin segment length of chromosomes 9 and 16. These results suggest a possible relationship between the quantitative changes of the constitutive heterochromatin of the chromosome 1 and malignant transformation. In the children with acute lymphoblastic leukaemia haterochromatic variants might present a genomic instability, and the additional cytogenetic chenges are required to produce a malignant fenotype.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita

Napomena
U-5

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