Naslov
Risk for atopy in children and adolescents with hyperreactive tuberculin skin test reaction

Autori
Turkalj, Mirjana ; Plavec, Davor ; Jelčić, Žaneta ; Kirin, Branka ; Vlašić, Željka ; Nogalo, Boro ; Zoričić-Letoja, Ivka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
Abstracts of the XXV Congress of the EAACI (EAACI 2006) / Valenta, R. ; Akdis, C. ; Bohle, B. - : EAACI, 2006, 80-81

Skup
Congress of the EAACI (25 ; 2006)

Mjesto i datum
Beč, Austrija, 10.06.2006. - 14.06.2006

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
adolescents; atopy; child; PPD; tuberculin test

Sažetak
Conflicting results about protective effects of infection with Mycobacterium tuberculosis and BCG vaccination on the incidence of atopic disorders exist in literature. The aim of our study was to investigate the prevalence of atopy in children and adolescents with hyperreactive tuberculin skin test (TST) reaction. One hundred and thirteen children and adolescents (54 boys, 59 girls ; mean age  SD , 14.6  3, 7 yrs) were evaluated for tuberculosis because of hyperreactive TST (indurations >14 mm) to protein purified derivative (PPD). They were also evaluated for atopy (family and medical history, clinical examination, skin prick test ; and specific and total IgE if indicated). Atopic disorder was present in 32 (28%) of tested patients. The size of induration in TST significantly discriminated patients with atopic disorders: <21 mm, 32, 9% ; 21-25 mm, 21, 9% ; >25 mm, 0%, P=0, 048. Multivariate logistic regression analysis depicted positive skin prick test and size of induration in TST as independent predictive factors for atopic disorder (odds ratios ; 40, 2, 95% CI 8, 5-189, P<0.01 ; 0.1, 95% CI 0.01-0.68, P=0.01 ; respectively). Compared with data gathered from general population of 15-year olds in Croatia about atopic disorders (13%) our patients showed significantly higher prevalence of atopy (P<0.001) which was associated only with induration size in TST <21 mm (P<0.001). In our selected group of patients with hyperreactive TST reactions the size of induration was an independent predictor of incident atopic disorder. These results could suggest that enhanced Th1 response may protect from atopic disorders.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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