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Pregled bibliografske jedinice broj: 252850

Increased genotoxicity of acetylaminofluorene by modulators of multixenobiotic resistance mechanism: studies with the fresh water clam Corbicula fluminea

Waldman, Petra; Pivčević, Branka; Müller, Werner E. G.; Zahn, Rudolf K.; Kurelec, Branko
Increased genotoxicity of acetylaminofluorene by modulators of multixenobiotic resistance mechanism: studies with the fresh water clam Corbicula fluminea // Mutation research. Genetic toxicology and environmental mutagenesis, 342 (1995), 3-4; 113-123 doi:10.1016/0165-1218(95)90021-7 (međunarodna recenzija, članak, znanstveni)

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Naslov
Increased genotoxicity of acetylaminofluorene by modulators of multixenobiotic resistance mechanism: studies with the fresh water clam Corbicula fluminea

Autori
Waldman, Petra ; Pivčević, Branka ; Müller, Werner E. G. ; Zahn, Rudolf K. ; Kurelec, Branko

Izvornik
Mutation research. Genetic toxicology and environmental mutagenesis (1383-5718) 342 (1995), 3-4; 113-123

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Multixenobiotic resistance (MXR) ; Multidrug resistance (MDR) ; Clam ; Corbicula fluminea ; P-170 glycoprotein ; Chemosensitizer

Sažetak
The presence of a ‘multixenobiotic resistance’ [MXR] mechanism in gills of the freshwater clam Corbicula flumenea was investigated. Western blot analyses of membrane vesicles from gills, applying antibodies to vertebrate P170 multidrug resistance (MDR) protein, revealed a 135 kDa immunoreactive protein. Verapamil caused a reduction of 3H-vincristine (3H-VCR) binding onto vesicles from calm. Exposure of calms to 3H-VCR in the presence of verapamil or staurosporine (STP) enhanced the accumulation of 3H-VCR over control values. Furthermore, clams were exposed instead to VCR, to a model carcinogen, 2-acetylaminofluorene (AAF), to determine the verapamil- and STP-dependent increase of single-strand breaks (SSBs) in DNA from gills of this organism. Verapamil caused no or little increase of SSBs induced by exposure to 0.01 or 0.10 μ M AAF, respectively, as measured by the alkaline elution technique. In contrast, in the presence of STP a highly significant and dose-dependent enhancement of AAF-mediated SSBs was measured already at exposure to 0.01 μ M AAF. These data indicate (i) that the calm C. fluminea is provided with a P-glycoprotein-like element of the MDR-mechanism, (ii) that this system can be poisoned by chemosensitizers such as verapamil and STP, (iii) the role of protein kinase C in the regulation of MXR function and (iv) the importance of the MXR modulators for the assessment of ecotoxicological effects of pollutants.

Izvorni jezik
Engleski

Znanstvena područja
Biologija



POVEZANOST RADA

Projekti:
1-08-146

Ustanove:
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Branka Pivčević Novak (autor)

Avatar Url Branko Kurelec (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com doi.org

Citiraj ovu publikaciju:

Waldman, Petra; Pivčević, Branka; Müller, Werner E. G.; Zahn, Rudolf K.; Kurelec, Branko
Increased genotoxicity of acetylaminofluorene by modulators of multixenobiotic resistance mechanism: studies with the fresh water clam Corbicula fluminea // Mutation research. Genetic toxicology and environmental mutagenesis, 342 (1995), 3-4; 113-123 doi:10.1016/0165-1218(95)90021-7 (međunarodna recenzija, članak, znanstveni)
Waldman, P., Pivčević, B., Müller, W., Zahn, R. & Kurelec, B. (1995) Increased genotoxicity of acetylaminofluorene by modulators of multixenobiotic resistance mechanism: studies with the fresh water clam Corbicula fluminea. Mutation research. Genetic toxicology and environmental mutagenesis, 342 (3-4), 113-123 doi:10.1016/0165-1218(95)90021-7.
@article{article, author = {Waldman, Petra and Piv\v{c}evi\'{c}, Branka and M\"{u}ller, Werner E. G. and Zahn, Rudolf K. and Kurelec, Branko}, year = {1995}, pages = {113-123}, DOI = {10.1016/0165-1218(95)90021-7}, keywords = {Multixenobiotic resistance (MXR), Multidrug resistance (MDR), Clam, Corbicula fluminea, P-170 glycoprotein, Chemosensitizer}, journal = {Mutation research. Genetic toxicology and environmental mutagenesis}, doi = {10.1016/0165-1218(95)90021-7}, volume = {342}, number = {3-4}, issn = {1383-5718}, title = {Increased genotoxicity of acetylaminofluorene by modulators of multixenobiotic resistance mechanism: studies with the fresh water clam Corbicula fluminea}, keyword = {Multixenobiotic resistance (MXR), Multidrug resistance (MDR), Clam, Corbicula fluminea, P-170 glycoprotein, Chemosensitizer} }
@article{article, author = {Waldman, Petra and Piv\v{c}evi\'{c}, Branka and M\"{u}ller, Werner E. G. and Zahn, Rudolf K. and Kurelec, Branko}, year = {1995}, pages = {113-123}, DOI = {10.1016/0165-1218(95)90021-7}, keywords = {Multixenobiotic resistance (MXR), Multidrug resistance (MDR), Clam, Corbicula fluminea, P-170 glycoprotein, Chemosensitizer}, journal = {Mutation research. Genetic toxicology and environmental mutagenesis}, doi = {10.1016/0165-1218(95)90021-7}, volume = {342}, number = {3-4}, issn = {1383-5718}, title = {Increased genotoxicity of acetylaminofluorene by modulators of multixenobiotic resistance mechanism: studies with the fresh water clam Corbicula fluminea}, keyword = {Multixenobiotic resistance (MXR), Multidrug resistance (MDR), Clam, Corbicula fluminea, P-170 glycoprotein, Chemosensitizer} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus

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