Naslov
Evaluation of the CAST assay in the detection of allergy to inhalant and food allergens in patients with atopic dermatitis

Autori
Milavec-Puretić, Višnja ; Lipozenčić, Jasna ; Branko, Malenica

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
Abstract Book EAACI 2006 / Valenta, Rudolf ; Akdis, Cezmi ; Bohle, Barbara - Beč, 2006

Skup
XXV Congress of the European Academy of Allergology and Clinical Immunology

Mjesto i datum
Beč, Austrija, 10.06.2006. - 14.06.2006

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
CAST test; food allergens; atopic dermatitis

Sažetak
Atopic dermatitis is a chronically recurrent inflammatory skin disorder characterized by eczematous skin lesions that affect 10-20% of population. Athouigh AD is sommonly detected in infancy and usually represents the first manifestation of atopy, it can present later in life and persist in adulthood. This chromic skin condition is associated with asthma and/or allergic rhinitis. Patients with atopic dermatitis have elevated serum IgE levels and positive immediate skin test results to variety of food and inhalant allergens. Although allergenspecific T cells amnd immunoglobulin E (IgE) are involved in the slinical responses to allergens, identification of relevant allergens is very difficult. In this study we evaluate the diagnostic poztential of cellular antigen stimulation test (CAST) in the diagnosis of hypersensitivity reactions to inhalant and food allergens in patients with atopic dermatitis and rhinitis. CAST test was based on sulfoleukotriene production after in vitro specific allergen cell stimulation. The reulsts of the study show that 28/42 patients had positive CAST to Der p ; 15/25 of patients to Der f ; 11/14 of patients to grass pollen ; 6/29 of patinets to milk ; 23/33 of patients to eggs ; 6/16 of patients to soya and 4/14 patients to wheat. We concluded that cellular releasibility by quantification of mediator production allows for better detection of hypersensitivity with ADS nad rhinitis

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA