Naslov
Primary Cutaneous Diffuse Large B Cell Lymphoma, Leg Type. A Case Report

Autori
Pašić, Aida ; Radoš, Jaka ; Lipozenčić, Jasna ; Čeović, Romana ; Radman Ivo

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Journal of Investigative Dermatology. Supplement. / Goldsmith, Lowell A. - Chapell Hill, 2006, S39-39

Skup
3^rd Meeting of the European Association of Dermato-Oncology

Mjesto i datum
Rim, Italija, 23.06.2006. - 25.06.2006

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
diffuse large B cell lymphoma; leg type; therapy

Sažetak
Primary cutaneous B-cell lymphomas (CBCL) are a heterogeneous group of B-cell lymphoproliferative diseases that are characterized by skin involvement without detectable extracutaneous disease at the time of diagnosis. In the new World Health Organization/European Organization for Research and Treatment of Cancer (WHO-EORTC) classification of cutaneous lymphoma, large B-cell lymphomas are divided into 3 groups: large B-cell lymphoma, leg type (LBCLLT), follicle center lymphoma, diffuse type (FCLDT) and large B-cell lymphoma, and other (LBCLO). We report on a 76-year-old female diagnosed with LBCLLT in November 2005. Brownish-red plaques and nodules of smooth surface, clustered on her left shoulder and in the right axilla, with two solitary foci on the abdomen and back, appeared one month and a half before hospitalization. Extracutaneous manifestations of the disease were ruled out by clinical examination and laboratory testing. A skin biopsy specimen showed a dense, diffuse lymphocytic infiltrate in the papillary and reticular dermis as well as in the subcutis, composed of large dysplastic lymphocytes with immunoblastic features. Paraffin immunoperoxidase studies identified the neoplastic cells as B cells, which were CD20, bcl 6, Mum-1 and bcl 2 positive. CD3, CD43 and CD10 stains produced negative results. The patient received 6 cycles of chemotherapy with cyclophosphamide, doxorubicin, vincristine and prednisone, which resulted in complete regression of the lesions. Until now, there has been no relapse of the disease. Close follow up is necessary because of the higher rate of recurrence and more unfavorable prognosis than in case of PCFCCL characterized by diffuse, large cell morphology.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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