Naslov
Metabolic Fate of Peptidoglycan Monomer from Brevibacterium divaricatum and Biological Activity of its Metabolites

Autori
Tomašić, Jelka ; Valinger, Zdenka ; Hršak, Ivo ; Ladešić, Branko

Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), znanstveni

Izvornik
Biological Properties of Peptidoglycan. Proceedings of the Second International Workshop / Seidl, P.H. ; Schleifer, K.H. - Berlin : Walter de Gruyter, 1986, 203-208

Skup
Biological Properties of Peptidoglycan

Mjesto i datum
München, Njemačka, 20.05.1985. - 21.05.1985

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Peptidoglycan monomer; N-actylmuramyl-L-alanine amidase

Sažetak
Peptidoglycan monomer (PGM) is the disaccharide-pentapeptide originating from Brevibacterium divaricatum. It was obtained by lysozyme digestion of uncrosslinked peptidoglycan chains isolated from the culture fluid of penicillin treated bacteria. PGM preparation contains up to 10% of anhydromuramyl analogue. Following i.v. administration PGM is rapidly excreted, partly as a pentapeptide, resulting from the action of N-acetylmuramyl-L-alanine amidase present in blood. It exhibits immunostimulating and antitumor activity in various experimental models in vivo and in vitro.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti, Biotehnologija

POVEZANOST RADA