Pregled bibliografske jedinice broj: 250081
N-glycosylation of Recombinant Therapeutic Glycoproteins in Plant Systems
N-glycosylation of Recombinant Therapeutic Glycoproteins in Plant Systems // Food Technology and Biotechnology, 45 (2007), 1; 1-10 (međunarodna recenzija, pregledni rad, znanstveni)
CROSBI ID: 250081 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
N-glycosylation of Recombinant Therapeutic Glycoproteins in Plant Systems
Autori
Balen, Biljana ; Krsnik-Rasol, Marijana
Izvornik
Food Technology and Biotechnology (1330-9862) 45
(2007), 1;
1-10
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni
Ključne riječi
N-glycosylation; transgenic plants; glycosyltransferases; sialic acid; recombinant protein; therapeutic glycoproteins
Sažetak
Transgenic plants have recently emerged as a promising system for low-cost and large-scale production of therapeutic proteins. Despite many advantages plants offer as hosts for expression of recombinant proteins, there are certain limitations caused by major structural differences between plant and mammalian N-linked glycans. Thus, the efforts are being made in order to eliminate, or at least minimize, plant-specific N-glycosylation as well as to supplement plant endogenous system with human glycosyltransferases to obtain "humanized" non-immunogenic N-glycans on plant-made pharmaceuticals aimed for human therapy.
Izvorni jezik
Engleski
Znanstvena područja
Biologija
POVEZANOST RADA
Projekti:
119-1191196-1200 - Diferencijalna ekspresija proteina u biljnim stanicama (Balen, Biljana, MZOS ) ( CroRIS)
073-0731674-0841 - Stanična i tkivna diferencijacija tijekom razvoja biljnih organa
Ustanove:
Prirodoslovno-matematički fakultet, Zagreb
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
