Naslov
Association of cyclooxigenase-2 immunoreactivity with tumor recurrence and disease progression in superficial urothelial bladder cancer

Autori
Mokos, Ivica ; Jakić-Razumović, Jasminka ; Mareković, Zvonimir ; Pasini, Josip

Izvornik
Tumori (0300-8916) 93 (2006); 124-129

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
bladder neoplasms; disease progression; local tumor recurrence; prostaglandin-endoperoxide synthase; urothelium

Sažetak
Aims and background: The main characteristic of urothelial bladder cancer is a clear predisposition to recurrence and disease progression. The aim of this study was to acess the possible relationship between cyclooxigenase-2 (COX-2) immunoreactivity in superficial urothelial bladder carcinoma and tumor grade, stage, number of recurrences and clinical disease progression. Methods: In this prospective study 70 consecutive patients who underwent transurethral resection for superficial urothelial bladder cancer were included. Tumor slides were immunohistochemically stained for COX-2, and COX-2 immunoreactivity in tumor and inflammatory stromal cells was categorized as negative or midly, moderately or strongly positive. Patients were followed up for 2 years, and during this period the possible association of COX-2 immunoreactivity with tumor stage and grade, number of recurrences and progression of disease was evaluated. Results: COX-2 immunoreactivity in tumor cells was found in 57 (81.4%) patients and did not correlate with tumor grade, stage of disease, number of recurrences, and progression of disease. COX-2 immunoreactivity in inflammatory cells was found in 16 of 57 patients with COX-2 positive tumors, and was significantly related to the number of recurrences, time to appearance of the first recurrence, and disease progression. Conclusions: COX-2 immunoreactivity in inflammatory stromal cells adjacent to the COX-2 positive tumor might be useful in clinical practice for selection of patients with a high risk of tumor recurrence and disease progression.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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