Naslov
Preparation, characterization and activity of palladium(II) halide complexes with diethyl 2-quinolylmethylphosphonate (2-dqmp). X-ray crystal structures of trans-[Pd(2-dqmp)2X2] (X=Cl, Br)

Autori
Tušek-Božić, Ljerka ; Matijašić, Ivanka ; Bocelli, Gabriele ; Calestani, Gianluca ; Furlani, Ariella ; Scarcia, Vito ; Papaioannou, Aristotelis

Izvornik
Journal of the Chemical Society. Dalton transactions (0300-9246) 2 (1991); 195-201

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
palladium(II) complex ; halide complex ; antitumor activity ; quinolylmethylphosphonate complex ; crystal structure

Sažetak
A series of new palladium(11) halide complexes with diethyl 2-quinolylmethylphosphonate (2-dqmp) were prepared and studied. Two types of square-planar palladium dihalide complexes, trans-[Pd(2-dqmp)2X2{; ; ; ; ; with the N-bonded monodentate ligand and cis-[Pd(2-dqmp)X2] where dqmp acts as a bidentate N, O-bonded chelate ligand, could be obtained by reaction of 2-dqmp with [PdX4]2- (X = Cl or Br) in neutral methanolic-aqueous solution. The ion-pair salt complexes, [2-Hdqmp]2[PdX4], containing the protonated quinoline ligand as cation and the square-planar tetrahalogenopalladate complex as anion, were isolated upon treatment of the ethanolic-aqueous solution with HX. The new complexes were identified and characterized by elemental and thermogravimetric analysis magnetic and conductometric measurements, and by infrared and H-1 NMR spectral studies. All were tested for cytostatic activity on KB and L1210 cell lines, but only [Pd(2-dqmp)2Br2] 2 displayed a significant anti-tumour effect in both systems. The molecular structures of the complexes [Pd(2-dqmp)2X2] (X = Cl, 1 ; Br, 2) were determined by single-crystal X-ray analysis. The crystals are triclinic, space group P1BAR, Z = 2, with other parameters: 1, a = 10.209(3), b = 9.812(3), c = 8.949(2) angstrom, alpha = 78.36(2), beta = 92.82(2), gamma = 111.60(2)-degrees, R = 0.0598, and R' = 0.0648 for 2982 observed reflections ; 2, a = 10.502(3), b = 9.405(3), c = 9.009(3) angstrom, alpha = 72.00(2), beta = 103.96(2), gamma = 100.63(2)-degrees, R = 0.0574, and R' = 0.0614 for 2033 observed reflections. Each complex has a trans square-planar structure, the palladium being co-ordinated by two halogen and two nitrogen atoms and lying at a centre of symmetry.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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