Naslov
Preparation, characterization and activity of palladium(II) halide complexes with diethyl 8-quinolylmethylphosphonate (8-dqmp). X-ray crystal structure of [8-dqmpH]2[PdCl4] 2H2O and [8-dqmpH]2[Pd2Br6]
(Preparation, characterization and activity of palladium(II) halide complexes with diethyl 8-quinolylmethylphosphonate (8-dqmp). X-ray crystal structure of [8-dqmpH]2[PdCl4]·2H2O and [8-dqmpH]2[Pd2Br6])

Autori
Tušek-Božić, Ljerka ; Matijašić, Ivanka ; Bocelli, Gabriele ; Sgarabotto, Paolo ; Furlani, Ariella ; Scarcia, Vito ; Papanioannou, Aristotelis

Izvornik
Inorganica chimica acta (0020-1693) 185 (1991), 2; 229-237

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
palladium(II) halide complexes ; quinolylmethylphosphonates ; antitumor activity ; crystal structure

Sažetak
The synthesis, spectroscopic and biological properties of the novel palladium(II) halide complexes with diethyl 8-quinolylmethylphosphonate (8-dqmp) have been reported. It was shown that the square planar complexes trans-[Pd(8-dqmp)2X2] were obtained by reaction of 8-dqmp with PdX4(2-) (X = Cl, Br) in the neutral ethanolic/aqueous solution. In the HX acidic medium the quinolinium salt complexes [8-dqmpH]2[PdX4] were isolated. They were converted by heating in methanol into the corresponding hexahalodipalladium salt complexes [8-dqmpH]2[Pd2X6]. The new complexes were characterized on the basis of elemental and thermogravimetric analysis, magnetic and conductance measurements, by the IR and H-1 NMR spectra and some X-ray crystal structure determinations. The complexes were tested for their cytostatic activity on KB and L1210 cell lines. The coordination behaviour of 8-dqmp as well as the spectral and biological properties of its complexes were compared with the results reported for the diethyl ester of 2-quinolylmethylphosphonic acid (2-dqmp) and its palladium(II) halide complexes. The molecular structures of the complexes [8-dqmpH]2[PdCl4].2H2O (3) and [8-dqmpH]2[Pd2Br6] (6) have been fully characterized by X-ray diffraction studies. The crystals of both complexes are triclinic, space group P1BAR, Z = 2, with lattice parameters for 3: a = 9.438(2), b = 9.481(2), c = 11.082(2) angstrom, alpha = 83, 4(1), beta = 107.5(1), gamma = 77.0(1)-degrees, the final R factors are R = 0.0481 and R' = 0.0551 for 3208 observed diffractometer collected reflections ; and for 6: a = 11.943(2), b = 10.644(2), c = 8.873(2) angstrom, alpha = 102.08(2), beta = 85.56(2), gamma = 69.54(2)-degrees, the final R factors are R = 0.0725 and R' = 0.0804 for 2584 observed diffractometer collected reflections. The structure of 3 is composed of the square planar PdCl4(2-) anion lying in a centre of symmetry (average Pd-Cl = 2.330 angstrom), of two quinolinium phosphonate cations and two water molecules. The structure of 6 consists of two quinolinium moieties as a cationic part separated by the Pd2Br6 centrosymmetric dianionic dimer.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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