Naslov
Chromosomal aberrations and variants of constitutive heterochromatin in infertile men

Autori
Buretić-Tomljanović, Alena ; Radojčić Badovinac, Anđelka ; Vlastelić, Ivica ; Randić, Ljiljana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
1st European Cytogenetics Conference : Abstracts ; u: Cytogenetics and Cell Genetics 77 (1997) (1/2 = Special Issue) / Baranov, V. ; Malet, P. ; Pangalos, C. - , 1997, 68-68

ISBN
978-3-8055-6549-3

Skup
European Cytogenetics Conference (1 ; 1997)

Mjesto i datum
Atena, Grčka, 22.06.1997. - 25.06.1997

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Chromosome; Heterochromatin; fertility

Sažetak
Cytogenetic analysis of 114 infertile men with different clinical diagnoses was done. The overall frequency of chromosomal aberrations was 15.79% (18/144). The frequency of chromosomal aberrations was highest in males with diagnosis of sterility (50% ; 2/4) ; in those with azoospermia or oligozoospermia the frequencies of chromosomal aberrationswere 25% (4/16) and 20.7% (5/23), respectively. In males with a diagnosis of hypogonadism or Klinefelter's syndrome, 15.4% (6/39) of chromosomal aberrationswas found. Karyotype 47, XXY was a predominant aberration in our sample making 55.5% of all aberration. In 32 males with other diagnosis one structural chromosomal aberration was found (3.1%). Among 97 males with normal karyotype, 30 were randomly selected for quantitative analysis of constitutive heterochromatin to investigate the possible influence of the amount of heterochromatin to human male fertility. Eighteen males of a normal fertility were additionaly analysed as a control. Relative lenght of the q chromosome arms of chromosomes 1, 9 and 16 using a transformation q/(p+q) and F/Y index were determined as a measure of a heterochromatin length variation. Measurement was made on GTG-banded metaphase chromosome. For the methodological reasons, inversions of heterochromatic segments of chromosome 9 were not included in this part of the study. Analysis of the heterochromatic segments' length revealed significantly longer heterochromatin segments of chromosome pair 16 in males with azoospermia or oligozoospermia than in the control (p=0.002). Y/F indeces were lower in 30 infertile males than in the control (p<0.05).

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita

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