Pregled bibliografske jedinice broj: 249745
Synthesis and antiviral activity of novel adamantylpeptides
Synthesis and antiviral activity of novel adamantylpeptides // Helvetica Chimica Acta, 76 (1993), 1752-1758 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 249745 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Synthesis and antiviral activity of novel adamantylpeptides
Autori
Vranešić, Branka ; Tomašić, Jelka ; Smerdel, Stanisalv ; Kantoci, Darko ; Benedetti, Fabio
Izvornik
Helvetica Chimica Acta (0018-019X) 76
(1993);
1752-1758
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
adamantyltripeptides; antiviral activity; influenza A virus
Sažetak
A novel type of compound that contains a peptide specific for bacterial peptidoglycans (immunomodulatory activity) and an adamantyl residue (antiviral activity) was synthesized. Thus, L-Ala-D-isoglutamine was linked to Gly(Ada) yielding two diastereoisomers, that were separated and characterized. The cytotoxic effect and antiviral activity of the novel adamantyltripeptides were studied. Both compounds exhibited low cytotoxicity for MDCK cells and reduced the infectivity of tested influenza A strains H1N1 and H3N2, but to a different extent on different strains.
Izvorni jezik
Engleski
Znanstvena područja
Kemija, Biologija, Temeljne medicinske znanosti
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
