Naslov
Effect of osmolality increase in brain ventricles, subarachnoid space and brain parenchyma on intracranial pressure

Autori
Klarica, Marijan ; Mitrović, Nenad ; Orešković, Darko ; Kudelić, Nenad ; Jukić, Tomislav ; Varda, Robert ; Bulat, Marin

Izvornik
Periodicum biologorum (0031-5362) 100 (1998), 2; 217-220

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
cerebrospinal fluid ; brain parenchyma ; osmolality ; intracranial pressure

Sažetak
Abstract Background and purpose: Wehave observed in experimental meningitis that an increase in cerebrospinal fluid (CSF) osmolality is much higher in lateral ventricle than in cisterna magna. Since a rise of CSF osmolality causes elevation of intracranial pressure (ICP) the question arises how the same osmolality applied in different CSF compartments and brain affects ICP. Material and methods: In experiments on anesthetized dogs (chloralose, 100 mg/kg i.p.)0, 95 mmol of sucrose was applied in lateral ventricles, cortical subarachnoidal space or brain tissue. Total volume of sucrose solution of 1 ml was applied in 100 ug steps and thereafter 100 ug of CSF from cisterna magna was removed to prevent significant changes in CSF pressure during sucrose application. Results: The application of sucrose into brain parenchyma evokes transient increase in ICP which did not differ significantly from the control value. When sucrose was applied into lateral ventricles the ICP very soon doubled, lasting over 20 min. Similar increase in ICP was observed after application of sucrose in cortical subarachnoid space but it soon declined toward control values. Conclusion: Our results show that the same osmolality applied in different parts of intracranial cavity causes dissimilar increase in ICP. This effect of osmolality on ICP seems to depend primarily on the capillary contact area and the osmotic gradient across capillary walls.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA