Pregled bibliografske jedinice broj: 249031
Bcl-2 exspression and apoptosis in non Hodgkin lymphomas
Bcl-2 exspression and apoptosis in non Hodgkin lymphomas // Virchows Archiv / Vilardo, Doris (ur.).
Heidelberg, 2003. str. 304-304 (poster, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 249031 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Bcl-2 exspression and apoptosis in non Hodgkin lymphomas
Autori
Stifter, S. ; Duletic-Nacinovic, A. ; Sever-Prebilic, M. ; Lucin, K. ; Jonjic, N.
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
Virchows Archiv
/ Vilardo, Doris - Heidelberg, 2003, 304-304
Skup
19th European Congress of Pathology
Mjesto i datum
Ljubljana, Slovenija, 06.09.2003. - 11.09.2003
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
bcl-2; apoptosis; Non Hodgkin's lymphoma
Sažetak
Introduction Non-Hodgkin lymphomas (NHL) are a heterogenous group of lymphoid malignancies classified according to their morphological, immunophenotypical and genotypical characteristics as well as their clinical behaviour. However, the progression of these diseases may be influenced by various others factors such as apoptosis, proliferation and angiogenesis. Aim: A possible correlation between Bcl-2 exspression, apoptosis, disease outcome and overall survival in patients with NHL was analysed. Materials and methods 72 NHL devided in low-(N=29) and high – grade (N=43) were immunohistochemicaly analysed for Bcl-2 expression , while 12 low- and 12 high - grade NHL were procesed for terminate TdT mediated dUTP nick end labeling (TUNEL) method in order to determine the apoptotic index of tumor cells. Results were obtained by image analyser and statistically processed. Results The exspression of Bcl-2 protein , as an antiapoptotic marker was significantlly higher in low- compared to high – grade NHL, p=0.024, wereas the apoptotic index obtained with the TUNEL method demonstrated inverse results, p<0.001. In high- grade NHL, partial remission was observed in patients whose tumors exspressed significantly higher values of Bcl-2, (p=0.03), while complete remission was observed in a group with a lower expression of Bcl-2. Furthermore, patients with lower Bcl-2 expression showed longer overall survival p=0.02, whereas patients with a higher apoptotic index showed shorter survival, p<0.001. In both low- and high- grade groups of NHL, Bcl-2 has been found as an independent predictor of patients disease relaps, p<0.05. Conclusion The expression of Bcl-2 is a strong independent predictor of disease progression in NHL patients.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
