Naslov
Long term vitamin C and E treatment and endothelial function in scuba-diving

Autori
Obad, Ante ; Palada, Ivan ; Valić, Zoran ; Dujić Željko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
The FASEB Journal / - , 2006, A1249-A1249

Skup
Experimental Biology 2006.

Mjesto i datum
San Francisco (CA), Sjedinjene Američke Države, 01.04.2006. - 05.04.2006

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
diving; endothelial function; gas bubbles; antioxidants

Sažetak
We have recently shown that a single air dive can lead to acute baseline arterial vasodilation and impairment of endothelium-dependent vasodilatation in man, which we believe is a combined effect of hyperoxia and bubble formation. We prospectively evaluated the effect of long-term antioxidants (1000 mg vitamin C and 400 IU vitamin E/day for 4 weeks) on arterial endothelial function before and after a single dive. Eight professional male divers with a mean age of 35.6? 3.6 years performed an open sea air dive to 30 m for 30 min. Before and after dives peak and 5-s postocclusion blood flow, shear rate, and brachial artery flow-mediated dilation (FMD) were assessed. The first dive without antioxidants produced moderate bubble load with a significant brachial arterial diameter increase from 3.85? 0.55 to 4.04? 0.5 mm and a significant reduction of FMD from 7.6? 2.7 to 2.8? 2.1% (p=0.0008). The second dive with antioxidants produced similar bubble load with unchanged arterial diameter (3.99? 0.37 vs. 4.01? 0.38) and significant reduction of FMD from 8.11? 2.4 to 6.8? 1.4% (p=0.044). FMD reduction was significantly smaller with antioxidants (p=0.0002). Similar responses were observed in normalized FMD (to shear rate), indicating unchanged shear rates at any time point. Peak and 5-s postocclusion flow rates and nitroglycerine-induced dilatation were unchanged with antioxidants. This study shows that long term antioxidants treatment can reverse baseline vasodilation and endothelial dysfunction in man that occurs even after a single dive.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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