Naslov
Simultaneous Appearance of Breast Cancer in a pregnant Woman and her Elder sister

Autori
Staklenac, Blaženka ; Trutin-Ostović, Karmen ; Hihlik-Babić, Irenka ; Pajtler, Marija ; Margaretić, Damir ; Dmitrović, Branko

Izvornik
Cytopathology (0956-5507) 11 (2000), 5;

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, kongresno priopcenje, ostalo

Ključne riječi
breast cancer; FNAC

Sažetak
Objective: Breast cancer is very rare in pregnancy and the postnatal period. FNA cytology is a very useful for distinquishing benign an malignant lesions. Study design: Ultrasound quided FNA of hypoechogenic left node in a 34-year-old woman in a 3 week pregnancy is performed. Cytological diagnosis of adenocarcinoma metastaticum lymphonody was established. It was histologically confirmed. Ablactation was made after delivery. After ablactation FNAC of clinically, mammographically and ultrasound suspicious lesion in outer lateral quadrant of left breast was performed. The cytological diagnosis of breast cancer was histologically cofirmed (negative for estrogen and progesteron expression, Katepsin D 66).At the same time her 5 year older sister had nonpalpable breast lesion which was cytologically as well as pathologically diagnosed as adenocarcinoma (estrogen 15, negative for progesteron expression, katepsin D 102). Flow cytometric DNA analysis of the breast tumors of two sisters were prepared from paraffin-embedded samples. According to the DNA histograms samples of the pregnant woman were diploid and the percentage of cells in the S phase was normal (14, 1%). Samples of her sister were aneuploid with two peaks in GO phase and percentage of cells in in the S phase was high (27, 6%) indicating unregulated proliferation. Conclusion: The combination of FNAC and flow cytometric DNA analysis can be very useful for improving cytological diagnosis and therapy of breast cancer especially in pregnancy and postnatal period.

Izvorni jezik
Engleski

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