Naslov
Participation in external quality assessment schemes for selenium, copper and zinc in serum

Autori
Jurasović, Jasna ; Pizent, Alica ; Telišman, Spomenka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of Abstracts. AOAC INTERNATIONAL Central Europe Subsection 5th International Symposium on Interpretation of Chemical, Microbiological and Biological Results and the Role of Proficiency Testing in Accreditation of Laboratories. Varaždin 1998. / Krauthacker, Blanka ; Raspor, Biserka - Zagreb : Institut za medicinska istraživanja i medicinu rada ; Institut Ruđer Bošković, 1998, P-24

Skup
AOAC INTERNATIONAL Central Europe Subsection 5th International Symposium on Interpretation of Chemical, Microbiological and Biological Results and the Role of Proficiency Testing in Accreditation of Laboratories.

Mjesto i datum
Varaždin, Hrvatska, 21.10.1998. - 23.10.1998

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Sažetak
Selenium (Se), copper (Cu) and zinc (Zn) are essential trace elements involved in many metabolic processes and enzyme systems, and have an important role in protection against oxidative stress which is implicated in pathogenesis of over 100 human diseases. The requirements of Se, Cu and Zn are interrelated, i.e. an increase or decrease of one determines the necessary body level for optimum function of the others. Accurate analysis of these elements in body fluids is necessary for evaluation of their role in human health. // This paper describes our participation in the United Kingdom National External Quality Assessment Schemes for Trace Elements (TEQAS), organised by the Robens Institute, University of Surrey. The Robens Institute was in 1979 the first initiator of external quality assessment schemes (EQAS) for trace metals in occupational and environmental laboratory medicine (OELM) in Europe. EQAS have been developed in various European countries over the course of the years and cover a broad range of analytes and matrices, but differ in their organisation and procedures for evaluation of analytical performance of participating laboratories. // Samples of bovine serum with unknown addition of Se, Cu and Zn are distributed by the TEQAS organiser 12 times per year, with three samples per trial, which makes 36 samples per year. Analysis results are reported at the end of each month (deadline), and overall results are then returned to participating laboratories within three weeks, with target values and laboratory monthly and cumulative performance score. Target values for the distributed control samples are consensus mean values, derived from the results provided by participants after exclusion of outliers. At the end of a six month cycle, cumulative scores are computed for proximity to the target value, recovery and precision on replicate specimens sent in different occasions. For example, according to the Six Monthly Cumulative Reports for serum Se for the periods April-September 1996, and October 1996 - March 1997, our results were categorised as being "Acceptable", while our Ranking was 3 and 1, respectively, from all of the ť 50 participating laboratories. // In conclusion, understanding of health effects and interactions between elements (toxic and essential) is based on laboratory analytical results, which makes it imperative that these results be of known and acceptable quality for intended use. Participation in external quality assessment schemes (EQAS) allows laboratories to assess their performance and is also regarded as a pre-requisite for accreditation from appropriate national or supranational bodies.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita

POVEZANOST RADA