Naslov
Characteristics of experimental allergic encephalomyelitis (EAE) induced by SMS 201-995 in EAE resistant (AO)rats

Autori
Muhvić, Damir ; Petković, Marija ; Radošević-Stašić, Biserka ; Rukavina, Daniel

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Periodicum Biologorum / Silobrčić, Vlatko - Zagreb : Hrvatsko prirodoslovno društvo, 1994, 271-271

Skup
Mechanisms in local immunity ; 2nd Alps-Adria Immunology and Allergology Meeting

Mjesto i datum
Opatija, Hrvatska, 26.09.1994. - 28.09.1994

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
experimental allergic encephalomyelitis; somatostatin; AO rats

Sažetak
We have previously shown that changes of neuro-endocrine homeostasis, induced by long acting somatostatin analog SMS-201-995, may abrogate the natural resistance of AO rats to the induction of EAE (inducibility of disease arose from 9 to 55%). In this work an attempt was made to correlate the changes noticed in clinical score of disease with the peripheral lymphatic status and functional reactivity of lymphocytes to specific and unspecific antigen challenge, as well as with the findings in CNS.For this purpose the phenotypic profile of cells in spleen and lymph nodes, blastic tranformation to Con A and myelin basic protein (MBP) and immunohistology in CNS were done. The time kinetic study has revealed that relaps and recovery phase of EAE in SMS-treated rats induces the characteristic changes in the proportion of W3/25, OX-8, OX-1 and OX-39 cells in spleen and variations in the intensity of blastic transformation to Con A. Before the relaps, the latter was significantly increased in comparison with saline treated group, indicating that SMS-induced changes in systemic immunity contribute to the altered susceptibility to EAE induction in resistant AO rats.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA