Naslov
Mapping of Mhc class I and class II regions to different linkage groups in the zebrafish, Danio rerio

Autori
Bingulac-Popović, Jasna ; Figueroa, Felipe ; Sato, Akie ; Talbot, William S. ; Johnson, Stephen L. ; Gates, Michael ; Postlethwait, John H. ; Klein, Jan

Izvornik
Immunogenetics (0093-7711) 46 (1997); 129-134

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
zebrafish; Mhc; class I; class II

Sažetak
The mammalian major histocompatibility complex (Mhc) consists of three closely linked regions, I, II and III, occupying a single chromosomal segment. The class I loci in region I and the class II loci in region II are related in their structure, function, and evolution.Region III, which is intercalated between regions I and II, contains loci unrelated to the class I and II loci, and to one another. There are indications that a similar Mhc organization exists in bird and amphibians. Here, we demonstrate that in zebrafish (Danio rerio), a representative of the teleost fishes, the class II loci are divided between two linkage groups which are distinct from the linkage group containing the class I loci. The b2-microglobulin-encoding gene is loosely linked to one of the class II loci. The gene coding for complement factor B, which is one of the region III genes in mammals, is linked neither to the class I nor to the class II loci in the zebrafish. These results, combined with preliminary data suggesting that the class I and class II regions in another order of teleost fish are also in different linkage groups, indicate that close linkage of the two regions is not necessary either for regulation of expression or for coevolution of the class I and class II loci. They also arise the question of whether linkage of the class I and class II loci in tetrapods is a primitive or derived character.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

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