Naslov
Comparison of Microvessel Density with Tumor Associated Macrophages in Invasive Breast Carcinoma

Autori
Jonjić, Nives ; Valković, Toni ; Lučin, Ksenija ; Iternička, Zlatko ; Krstulja, Mira ; Mustać, Elvira ; Dobi-Babić, Renata ; Sasso, Franco ; Melato, Mauro

Izvornik
Anticancer research (0250-7005) 18 (1998); 3767-3770

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
angiogenesis; TAM; breast carcinoma

Sažetak
Neovascularisation, the growth and formation of capillary blood vessels, is an essential component of solid tumor growth and a critical step in metastasis. Tumor associated macrophages (TAMs) have several functions related to tumor biology including growth, proliferative rate, stroma formation and dissolution and neovascularisation. The aim of this study was to define the TAM and microvessel density in human invasive breast carcinoma NOS and to correlate their values with lymph node status, tumor size, tumor grade and mitotic activity index (MAI) and, finally, to determine whether MD is connected with TAMs. A total number of 57 invasive breast carcinomas NOS were processed for immunohistochemical analysis using mAb to F-VIII to visualize endothelial cells and mAb to CD68 antigens for macrophages. Statistical analysis showed only a positive correlation between TAMs and MAI (p=0.004). These results support the notion that intensity of tumor angiogenesis does not provide additional prognostic significance, while TAMs may play a positive role in breast cancer microsystem since they regulate tumor proliferation.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA