Pregled bibliografske jedinice broj: 24443
Antiproliferative effects of new synthetise DNA-intercalators
Antiproliferative effects of new synthetise DNA-intercalators // FEBS 96, 24th meeting of the federation of european biochemical societies
Barcelona: Federation of European Biochemical Societies (FEBS), 1996. (poster, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 24443 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Antiproliferative effects of new synthetise DNA-intercalators
Autori
Steiner-Biočić, Ivka ; Glavaš-Obrovac, Ljubica, Pavelić, Krešimir
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
FEBS 96, 24th meeting of the federation of european biochemical societies
/ - Barcelona : Federation of European Biochemical Societies (FEBS), 1996
Skup
FEBS 96, 24th meeting of the federation of european biochemical societies
Mjesto i datum
Barcelona, Španjolska, 07.06.1996. - 12.06.1996
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
DNA- intecalators; tumor cell lines
Sažetak
We have investigated the antiproliferative and cytotoxic effects of planar 4,9-dimethyl-4,9 diazapyrenium and 2,4,7,9-tetramethyl-4,9 diazapyrenium hydrogensulphates against human malignat MiaPaCa2 (pancreatic carcinoma), Hep2 (laryngeal carcinoma9 and human normal fibroblasts (WI 38) cell lines. The tested compounds were found to be very potent to inhibiting the growth of the treated cell lines. Treatment with molar concentration of substances (10-4 - 10-7 M) was capable of causong 50% and more growth inhibition. The morphological changes on treated cells were observed. The identification and the appearance of chromatin aggregation leads us to assume the apoptosis or programed cell death of investigated tumor cell lines induced by the applying planar cyclic compounds.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
