Pregled bibliografske jedinice broj: 244340
Potential therapeutic targets in Alzheimer's disease
Potential therapeutic targets in Alzheimer's disease // Acta Pharmaceutica, 47 (1997), 1; 1-7 (međunarodna recenzija, pregledni rad, znanstveni)
CROSBI ID: 244340 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Potential therapeutic targets in Alzheimer's disease
Autori
Simonić, Ante ; Župan, Gordana
Izvornik
Acta Pharmaceutica (1330-0075) 47
(1997), 1;
1-7
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni
Ključne riječi
Alzheimer's disease; therapy; cholinergic neurotransmission; excitatory amino acid; Ca2+; free radicals beta amyloid; tau protein; neurotrophic factors
Sažetak
Alzheimer's disease (AD) is a common, heterogeneous age related degenerative dementia of unknown etiology and multifactorial origin. It is characterized by a progressive loss of intellectual function. At present there is no available treatment that can cure, reverse or stop progression of AD. The basic strategies for potentially effective treatment for AD are: compensation of cholinergic deficit, blockade of excitatory amino acid receptor overstimulation, blockade of excessive influx of extracellular Ca2+, decrease of free acids and free radicals accumulation, blockade of beta amyloid deposition and hyperphosphorylation of tau protein, and apoptosis prevention.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
Citiraj ovu publikaciju:
Časopis indeksira:
- Scopus
