Naslov
Concentration-dependent effects of peroxovanadium compound bpV (phen) on PC12 cell survival
(Concentration-dependent effects of peroxovanadium compound bpV (phen) on PC12 cell survival survival)

Autori
Rumora, Lada ; Barišić, Karmela ; Petrik, Jozsef ; Žanić-Grubišić, Tihana

Izvornik
Croatica Chemica Acta (0011-1643) 78 (2005), 3; 419-425

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
peroxovanadium; MAPK; caspase; apoptosis; PC12 cells

Sažetak
Peroxovanadium compounds are potent insulinomimetic agents and protein tyrosine phosphatase inhibitors. In this study we have examined the potential toxicity of peroxovanadium complex bpV (phen) on rat pheochromocytoma PC12 cells, and we have explored the mechanism by which this compound influences cell survival and/or death. BpV (phen) exerted bimodal effect on PC12 cells: survival-enhancing effect at lower and death-inducing effect at higher micromolar concentrations. 1 and 3  M bpV (phen) intensely induced ERK activation. In contrast, 10 and 100  M bpV (phen) stimulated strong and sustained JNK and p38 MAPK activation as well as caspase-3 activation that preceded bpV (phen)-induced apoptotic cell death. We suggest that bpV (phen) might exert its action on PC12 cell survival by modulation of MAPKs and caspase-3 activation.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija

POVEZANOST RADA