Naslov
Frequency of HPA-15-a and HPA-15b (Gov a/b) human platelet alloantigens in the Croatian population

Autori
Tomičić, Maja ; Bingulac-Popović, Jasna ; Dražić, Vesna ; Hundrić Hašpl, Željka

Izvornik
Archives of Medical Research (0188-4409) 37 (2006), 1; 172-174

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Hrvatska populacija; humani trombocitni antigeni; novorođenačka aloimuna trombocitopenija; antitrombocitna protutijela; imobilizacija trombocitnih antigena monoklonskim protutijelima
(Croatian population; human platelet antigens 15a; 15b; frequency; neonatal alloimmune thrombocytopenia; antiplatelet antibody; monoclonal antibody immobilization of platelet antigens)

Sažetak
Human platelet antigens (HPA) genotyping is important for epidemiological studies because the prevalence of particular HPA allotypes differs among various populations and plays a major role in the ocurrence of HPA alloimmunization. In Caucasians, antibodies to HPA-1a are the most important causes of neonatal alloimmune thrombocytopenia (NATP). Recent studies suggest that anti-HPA 15a/15b (Gov b, Gov a) might be the most likely candidateantibodies following anti-HPA-1a in inducing NATP. METHOD: In the present study, HPA-15 system genotype was determined by PCR-SSP method in 279 unrelated subject from the Croatian population, yielding an HPA-15a and HPA-15b frequency of 0.53 and 0.47 respectively. RESULTS: retrograde testing for presence of anti-HPA 15 antibodies by use of MAIPA in 39 frosen serum samples fromserologically negative cases of clinically suspect NATP produced negative results. CONCLUSION: The clinical role of anti-HPA-15 alloantibodies was unable to be confirmed.

Izvorni jezik
Engleski

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