Naslov
Albumin Labeled with Gd-DTPA as an Intracavscular, Blood Pool-Enhancing Agent for MR Imaging: Biodistribution and Imaging Studies
(Intracavscular, Blood Pool-Enhancing Agent for MR Imaging: Biodistribution and Imaging Studies)

Autori
Schmiedl, Udo ; Ogan, Marc ; Paajanen, Hannu ; Marotti, Miljenko ; Crooks, Lawrence E ; Brito, Antonio C ; Brasch, Robert

Izvornik
Radiology (0033-8419) 162 (1987); 205-210

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Albumin ; blood ; volume contrast media ; Magnetic resonance (MR)

Sažetak
Albumin is a macrommolecule that remains largely confined to the vascular space after intravenous administration.Human serum albumin was paramagnetically labeled by covalently binding from nine to 18 gadolinium - DTPA (diethylenetri- aminepentaacetic acid) chelates perprotein molecule.This conjugate was tested in varying doses for in vivo biodistribution and effectiveness in tissue relaxation. After intravenous injection of the agent in rats T1 relaxation times were significantly reduced in samples of the blind and in lung, heart, spleen kidney, and brain tissue.These efects persisted at a relatively constant level for the next 30 minutes.In vivo magnetic resonance imaging heart and lungs of rats and rabbits confirmed the prolonged contrast-enhancing effect of the labeled albumin.These preliminary studies indicate that paramagnetically labeled macromolecules that distribute in the intravascular space may effective fr MR imaging evaluation of tissue blood volume.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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