Naslov
Francisella tularensis-biološko oružje

Autori
Šantić, Marina

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, neobjavljeni rad, znanstveni

Skup
Godišnja skupština Hrvatskog mikrobiološkog društva

Mjesto i datum
Zagreb, Hrvatska, 23.02.2006

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Nije recenziran

Ključne riječi
tularemija; bioterorizam
(tularemia; bioterrorisam)

Sažetak
Francisella tularensis is an aerobic, nonsporulating, gram-negative facultative intracellular bacterium that can cause a fatal disease, tularemia, in humans and animals. Because of the ease of its dissemination, multiple routes of infection, high infectivity, and lethality, F. tularensis has been classified as a potential bioterrorism agent. Although F. tularensis subsp. novicida is attenuated in humans it causes tularemia in mice that is similar to that caused by subsp. tularensis and is an attractive model to study pathogenesis of the disease. The intracellular lifestyle of F. tularensis is unique compared to all other described intracellular pathogens.In addition, nothing has been published about the role of IglD and MinD proteins in pathogenesis of the disease. Our experiments will reveal the role of these proteins for virulence factors of the bacteria, pathogenesis of the disease and future possibilities for vaccine design and application in order to prevent the epidemic of the tularaemia as a potential use for biological weapon.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA