Naslov
Met-enkephalin induced escape from dexamethasone immunosuppression

Autori
Haberstock Debić, Helena ; Marotti, Tatjana

Izvornik
Neuropeptides (0143-4179) 25 (1993), 3; 199-206

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Met-enkephalin ; dexamethasone

Sažetak
The present study was undertaken to examine whether and what type of interaction occurs between a synthetic glucocorticoid, dexamethasone (DEX) and an opioid peptide, met-enkephalin (MENK) upon superoxide anion (O2−) release from human polymorphonuclear cells (PMN). MENK (10−8 M) abolished suppressed O2− release from PMNs treated with 10−7 M DEX. This was the case in unstimulated but not in PMNs stimulated with PMA. The effect of MENK was mediated through pertussis-toxin (PTX) sensitive G-protein and since it was abolished by H7 probably involves protein kinase C (PKC) as a second messenger system. Thus, MENK can abolish DEX induced suppression of O2− release from human PMNs possibly through the interaction of second messenger pathways.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA