Naslov
Allogeneic reactivity of maternal lymphoid cells during the course of gestation. Modifications and sex differences in a local GVH assay

Autori
Dorić, Miljenko ; Kinsky, Radslav G. ; Voisin, Guy A.

Izvornik
Journal of reproductive immunology (0165-0378) 6 (1984); 187-195

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
allogeneic reactivity ; pregnancy ; GVH assay

Sažetak
The immune reactivity of lymphoid cell from pregnant mice was studied during the course of pregnancy in primiparous and multiparous animals either "isopregnant" (male and female of same strain) or "allopregnant" (male and female differing at H-2), using a local GVH assay (CBA lymphoid cells injected into (CBA x A/J)F1 recipients). The findings were as follows: (1) The lymphoid cell number in the para-aortic lympha nodes (PALN) was increased at all stages of gestation. The peak occurred in the 2nd week in primiparity and as early as 60 h after fertilization in multiparity. (2) PALN cell alloreactivity was weak at the beginning and higher than normal in the third week of pregnancy. (3) Spleen cell alloreactivity was increased in the second week and decreased in the third week in primipparous compared with multiparous animals. (4). Anti-paternal alloreactivity exhibited by spleen cells of allogestation was decreased (ac compared to cells of isogestation) especially in primiparous mice, particularly in the third week. At this time, the anti-paternal alloreactivity of PALN cells was increased. (%) The influence of the recipient's sex on GVHR intensity was reversed when the cells were obtained from a pregnant donor, becoming stronger in male compared with female hybrids.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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